Role of luteolin in overcoming Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting elderly people (>60 years old) worldwide. There is no permanent cure for the disease but the symptomatic relief can be obtained by using dopamine agonists besides L-dopa therapy. The longer use of the drugs is associated with several side effects. Hence, the researchers have made a considerable attention toward the development of neuroprotective agents from plants. A number of phytochemicals have been demonstrated for their protective effects in various in vitro, in vivo, and clinical studies. In this context, luteolin, a flavone which is present in fruits and vegetables has been attributed to a number of pharmacological properties including neuroprotective. The present review demonstrates the bioavailability, oral absorption, and mechanism of action against PD.

Automated summary

Parkinson's disease is the second most common neurodegenerative disorder affecting elderly people worldwide. While there is no permanent cure for the disease, symptomatic relief can be obtained through the use of dopamine agonists. Researchers are now focusing on the development of neuroprotective agents from plants to combat the side effects associated with long-term drug use.