Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1875, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2020.188495
Keywords
Cancer; Receptor tyrosine kinase; DNA repair; Inhibition
Categories
Funding
- Ligue contre le Cancer [44 et 22]
Ask authors/readers for more resources
Receptor Tyrosine Kinases (RTKs) play a crucial role in cancer cell survival and are relevant targets in cancer research. Recent studies have shown a close relationship between RTK signaling and DNA repair regulation, providing new research directions for the development of therapeutic strategies targeting both pathways.
Receptor Tyrosine Kinases (RTK) are an important family involved in numerous signaling pathways essential for proliferation, cell survival, transcription or cell-cycle regulation. Their role and involvement in cancer cell survival have been widely described in the literature, and are generally associated with overexpression and/or excessive activity in the cancer pathology. Because of these characteristics, RTKs are relevant targets in the fight against cancer. In the last decade, increasingly numerous works describe the role of RTK signaling in the modulation of DNA repair, thus providing evidence of the relationship between RTKs and the protein actors in the repair pathways. In this review, we propose a summary of RTKs described as potential modulators of double-stranded DNA repair pathways in order to put forward new lines of research aimed at the implementation of new therapeutic strategies targeting both DNA repair pathways and RTK-mediated signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available