Related references
Note: Only part of the references are listed.Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen
Mauro Torti et al.
PLATELETS (2020)
Identification of PtdIns(3,4)P2 effectors in human platelets using quantitative proteomics
Tom N. Durrant et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
Ivana Bertovic et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)
Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
Maria Selvadurai et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Phosphatidylinositol 3-monophosphate: A novel actor in thrombopoiesis and thrombosis
Colin Valet et al.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)
PI3K inhibitors in thrombosis and cardiovascular disease
Tom N. Durrant et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2020)
PI3K isoforms in cell signalling and vesicle trafficking
Benoit Bilanges et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Structural mechanism for Bruton's tyrosine kinase activation at the cell membrane
Qi Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Class II PI3K Functions in Cell Biology and Disease
Federico Gulluni et al.
TRENDS IN CELL BIOLOGY (2019)
How is the acyl chain composition of phosphoinositides created and does it matter?
David Barneda et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition
Maria V. Selvadurai et al.
FEBS LETTERS (2019)
Class I PI3Ks in arterial thrombosis
Pierre-Alexandre Laurent et al.
AGING-US (2019)
ELMO1 deficiency enhances platelet function
Akruti Patel et al.
BLOOD ADVANCES (2019)
PI3Kβ-A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling
Anne R. Bresnick et al.
ENDOCRINOLOGY (2019)
Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation
Abdulrahman Mujalli et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
The lipid products of phosphoinositide 3-kinase isoforms in cancer and thrombosis
Typhaine Anquetil et al.
CANCER AND METASTASIS REVIEWS (2018)
Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation
T. A. Blair et al.
CELLULAR SIGNALLING (2018)
Impact of PI3K (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis
Pierre-Alexandre Laurent et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Platelet activation and prothrombotic properties in a mouse model of peritoneal sepsis
Fanny Vardon Bounes et al.
SCIENTIFIC REPORTS (2018)
A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding
Constance C. F. M. J. Baaten et al.
BLOOD (2018)
The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling
Anthony M. Battram et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Benoit Bilanges et al.
NATURE COMMUNICATIONS (2017)
Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3) P-Directed Function of NADPH Oxidase
Yangyang Liu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth
Colin Valet et al.
BLOOD (2017)
A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies
Dejan Juric et al.
CLINICAL CANCER RESEARCH (2017)
In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
Tom N. Durrant et al.
BLOOD ADVANCES (2017)
Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy
Rana Mansour et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
Jonathan M. Backer
BIOCHEMICAL JOURNAL (2016)
Phosphoinositides: Important lipids in the coordination of cell dynamics
Julien Viaud et al.
BIOCHIMIE (2016)
Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability
Claire Petitjean et al.
PLATELETS (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
The class I phosphoinositide 3-kinases α and β control antiphospholipid antibodies-induced platelet activation
Anne-Dominique Terrisse et al.
THROMBOSIS AND HAEMOSTASIS (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
PI3Kβ inhibition: all that glitters is not gold
Mauro Torti
BLOOD (2015)
Essential role of class II PI3K-C2α in platelet membrane morphology
Colin Valet et al.
BLOOD (2015)
PI3K inhibitors in inflammation, autoimmunity and cancer
Anne-Katrien Stark et al.
CURRENT OPINION IN PHARMACOLOGY (2015)
RASA3 is a critical inhibitor of RAP1-dependent platelet activation
Lucia Stefanini et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase inhibition and aspirin in man
S. Nylander et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
Antiplatelet drugs: which targets for which treatments?
C. Gachet
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function
Jessica K. Mountford et al.
NATURE COMMUNICATIONS (2015)
Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate
Pierre-Alexandre Laurent et al.
BLOOD (2015)
Phosphoinositide 3-Kinases p110α and p110β Have Differential Roles in Insulin-Like Growth Factor-1-Mediated Akt Phosphorylation and Platelet Priming
Thomas A. Blair et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
Kay O. Schink et al.
BIOESSAYS (2013)
PDK1 regulates platelet activation and arterial thrombosis
Xue Chen et al.
BLOOD (2013)
Regulation of platelet plug formation by phosphoinositide metabolism
Sang H. Min et al.
BLOOD (2013)
Development of PI3K inhibitors: lessons learned from early clinical trials
Jordi Rodon et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2013)
ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β
Kelly A. O'Brien et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples
Gaetan Chicanne et al.
BIOCHEMICAL JOURNAL (2012)
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling
Alessandra Consonni et al.
BLOOD (2012)
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
Julia M. Burkhart et al.
BLOOD (2012)
Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!
S. P. Jackson et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)
Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor
S. Nylander et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)
Combined Blockade of ADP Receptors and PI3-Kinase p110β Fully Prevents Platelet and Leukocyte Activation during Hypothermic Extracorporeal Circulation
Stefanie Krajewski et al.
PLOS ONE (2012)
CELL BIOLOGY G Protein-Coupled Receptor-Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
Hashem A. Dbouk et al.
SCIENCE SIGNALING (2012)
An important role for Akt3 in platelet activation and thrombosis
Kelly A. O'Brien et al.
BLOOD (2011)
Arterial thrombosis-insidious, unpredictable and deadly
Shaun P. Jackson
NATURE MEDICINE (2011)
Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways
Analia Garcia et al.
BIOCHEMICAL JOURNAL (2010)
PTEN regulates collagen-induced platelet activation
Zhen Weng et al.
BLOOD (2010)
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
Valerie Martin et al.
BLOOD (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Akt signaling in platelets and thrombosis
Donna S. Woulfe
EXPERT REVIEW OF HEMATOLOGY (2010)
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
Chris I. Jones et al.
BLOOD (2009)
Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation
Karen Gilio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets
Soochong Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Twice upon a time: PI3K's secret double life exposed
Emilio Hirsch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Mechanisms of disease: Mechanisms of thrombus formation
Bruce Furie et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Selective inhibition of the platelet phosphoinositide 3-kinase p110 beta as promising new strategy for platelet protection during extracorporeal circulation
Andreas Straub et al.
THROMBOSIS AND HAEMOSTASIS (2008)
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway
Ingeborg Hers
BLOOD (2007)
Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform
Soochong Kim et al.
BLOOD (2007)
Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation:: insights into the mechanism of PLCγ2 activation
Ashraf Ragab et al.
BLOOD (2007)
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin αIIbβ3 adhesive function in platelets
Simone M. Schoenwaelder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Signalling through class I PI3Ks in mammalian cells
P. T. Hawkins et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Continuous signaling via PI3K isoforms β and γ is required for platelet ADP receptor function in dynamic thrombus stabilization
Judith M. E. M. Cosemans et al.
BLOOD (2006)
Signaling through PI3K gamma: a common platform for leukocyte, platelet and cardiovascular stress sensing
E Hirsch et al.
THROMBOSIS AND HAEMOSTASIS (2006)
The relative role of PLCβ and PI3Kγ in platelet activation
LR Lian et al.
BLOOD (2005)
Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets
YA Senis et al.
PLATELETS (2005)
PI 3-kinase p110β:: a new target for antithrombotic therapy
SP Jackson et al.
NATURE MEDICINE (2005)
Phosphoinositide 3-kinases and the regulation of platelet function
SP Jackson et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
D Woulfe et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
JH Chen et al.
BLOOD (2004)
SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels
S Giuriato et al.
BIOCHEMICAL JOURNAL (2003)
A PLCγ2-independent platelet collagen aggregation requiring functional association of GPVI and integrin α2β1
P Mangin et al.
FEBS LETTERS (2003)
A critical role of lipid rafts in the organization of a key FcγRIIa-mediated signaling pathway in human platelets
S Bodin et al.
THROMBOSIS AND HAEMOSTASIS (2003)
Human platelets contain p110δ phosphoinositide 3-kinase
J Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
S Krugmann et al.
MOLECULAR CELL (2002)
Resistance to thromboembolism in PI3Kγ-deficient mice
E Hirsch et al.
FASEB JOURNAL (2001)
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk
K Saito et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
