Journal
BEHAVIOURAL PHARMACOLOGY
Volume 32, Issue 1, Pages 54-61Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0000000000000602
Keywords
extinction; lateral hypothalamus; orexin system; rat; reward; ventral tegmental area
Ask authors/readers for more resources
This study aimed to investigate the influence of intra-VTA orexin receptors on the duration of CPP extinction period induced by LH stimulation, and found that OXRs in the VTA play crucial roles in the maintenance of reward processes.
The orexinergic connection between the lateral hypothalamus (LH) and the ventral tegmental area (VTA) is involved in modulating the reward circuit. The conditioned place preference (CPP) can be induced by microinjection of carbachol, a cholinergic agonist, into the LH. The current research was conducted to understand whether intra-VTA orexin receptors (OXRs) could influence the duration of the extinction period or maintenance of the intra-LH carbachol-induced CPP. To this end, the rats unilaterally received intra-LH carbachol (250 nM) within a 3-day conditioning period. Animals that have already passed the conditioning test were unilaterally administered by intra-VTA microinjection of SB334867, an OX1R antagonist, or TCS OX2 29, an OX2R antagonist during the extinction phase of the LH stimulation-induced CPP. For the first time, our data indicated that daily intra-VTA administration of either SB334867 (30 nM) or TCS OX2 29 (10 and 30 nM) during the extinction period decreased the maintenance of intra-LH carbachol-induced CPP. In conclusion, OXRs in the VTA play crucial roles in the maintenance of reward processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available