Journal
AUTOPHAGY
Volume 17, Issue 11, Pages 3375-3388Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2021.1872886
Keywords
Arabidopsis thaliana; autophagy; cargo receptor; ER-Phagy; organelle degradation; reticulophagy; TOR
Categories
Funding
- Israel Science Foundation [612/16]
- Israel's Council for Higher Education Planning and Budgeting Committee (VATAT) postdoctoral fellowship
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In this study, a reticulophagy pathway in Arabidopsis thaliana triggered by dark-induced starvation but not by ER stress was characterized, defined by the ATG8-interacting proteins ATI1 and ATI2. The ER-localized MSBP1 was identified as an ATI1- and ATI2-interacting protein and autophagy cargo, with ATI1 and ATI2 serving as its cargo receptors. These findings expand knowledge on plant responses during energy deprivation.
Reticulophagy, the selective autophagy of endoplasmic reticulum (ER) components, is known to operate in eukaryotes from yeast and unicellular algae to animals and plants. Thus far, only ER-stress induced reticulophagy was reported and analyzed in plants. In this study we characterize a reticulophagy pathway in Arabidopsis thaliana that is triggered by dark-induced starvation but not by ER stress. This pathway is defined by the previously reported ATG8-interacting proteins, ATI1 and ATI2. We further identified the ER-localized MSBP1 (Membrane Steroid Binding Protein 1) as an ATI1- and ATI2-interacting protein and an autophagy cargo, and show that ATI1 and ATI2 serve as its cargo receptors. Together, these findings expand our knowledge on plant responses during energy deprivation and highlight the role of this special type of reticulophagy in this process.
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