Journal
ARCHIVES OF VIROLOGY
Volume 166, Issue 1, Pages 275-280Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-020-04873-3
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Funding
- JSPS KAKENHI [19K10595]
- Science and Technology Research Partnership for Sustainable Development [19jm0110019h0002]
- Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED) [JP18fk0108017, JP20fk0108097]
- National Science Foundation of Sri Lanka [RPHS/2016/CKDu/06]
- Grants-in-Aid for Scientific Research [19K10595] Funding Source: KAKEN
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This study aimed to investigate the infectivity of shrew-borne hantaviruses to humans through the preparation of recombinant nucleocapsid proteins. Results showed no antigenic cross-reactivity among different hantaviruses’ rN proteins, and some samples reacted with ALTV and TPMV rN proteins. Further application of the novel assays is recommended for studying the potential infectivity of shrew-borne hantaviruses to humans.
The infectivity of shrew-borne hantaviruses to humans is still unclear because of the lack of a serodiagnosis method for these viruses. In this study, we prepared recombinant nucleocapsid (rN) proteins of Seewis orthohantavirus, Altai orthohantavirus (ALTV), Thottapalayam thottimvirus (TPMV), and Asama orthohantavirus. Using monospecific rabbit sera, no antigenic cross-reactivity was observed. In a serosurvey of 104 samples from renal patients and 271 samples from heathy controls from Sri Lanka, one patient serum and two healthy control sera reacted with rN proteins of ALTV and TPMV, respectively. The novel assays should be applied to investigate potential infectivity of shrew-borne hantaviruses to humans.
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