Journal
ARCHIVES OF MEDICAL RESEARCH
Volume 52, Issue 4, Pages 357-361Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2020.12.004
Keywords
Cystic fibrosis; Pseudomonas aeruginosa; Bacterial pathogenesis; Virulence factors
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Funding
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica, UNAM (PAPIIT) [IN224419]
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Cystic fibrosis is a genetic disease that affects the respiratory and digestive systems, causing chronic lung infections and breathing difficulties. Mutations in the CFTR gene lead to imbalanced intracellular water content, resulting in sticky mucus and bacterial infections that ultimately affect lung function.
Cystic fibrosis (CF) is a progressive autosomal recessive genetic disease that principally affects the respiratory and digestive systems. It is a chronic disease that has no cure. Symptoms often include chronic cough, lung infections, and shortness of breath. Children with cystic fibrosis present failure to thrive as manifested by low weight and height for age. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene that codes for a cell membrane protein of epithelial tissues and affects multiple organ systems in the human body. Mutations on the CFTR causes dysfunctional electrolyte regulation affecting intracellular water content. Defective CFTR function in airways produce a dehydrated and sticky mucus that leads the establishment of bacterial chronic infection that ultimate decrease the lung function. During the first decade of life, affected individuals are colonized principally by non typable Haetnophilus influenzae and Staphylococcus aureus. During the second decade, Pseudomonas aeruginosa becomes the most dominant pathogen and persists throughout the remainder of their lives. In this work, we describe the mechanisms used by P. aeruginosa to adapt and persist in lungs of individuals with cystic fibrosis. (C) 2020 IMSS. Published by Elsevier Inc.
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