Journal
ARCHIVES OF MEDICAL RESEARCH
Volume 52, Issue 3, Pages 339-347Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2020.11.012
Keywords
Obesity; Treg cells; Th17 cells; Type 2 diabetes mellitus; Glucose intolerance
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Funding
- Key Research & Development Plan, Hunan, China [2016JC2071]
- Xiangya Hospital-Peking Weiming Clinical and Rehabilitation Research Fund [xywm2015I29]
- 2018 hunan provincial science and technology department science and technology innovation and entrepreneurship environment construction special project-science popularization special project [2018ZK4033]
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The study found that the severe imbalance of peripheral Treg/Th17 ratio in overweight/obese patients may be a risk factor for diabetes and impaired glucose regulation.
Background. Chronic low-grade inflammation and dysfunction of metabolism has been reported to be involved in obesity. Regulatory T cell (Treg) and helper T cell 17 (Th17) are involved in chronic inflammatory diseases. Impaired balance of Treg/Th17 is one of the major factors contributing to inflammatory status in obesity. Methods. Overweight/obese patients (n = 80) were recruited and classified into three subgroups: normal glucose tolerance group (NGT, n = 32), impaired glucose regulation group (IGR, n = 19) and type two diabetes mellitus group (T2DM, n = 29). Healthy individuals were paired as normal control group (NC, n = 37). We used flow cytometry to test the frequencies of circulating Treg and Th17 cells of all subjects. Serum IL-6, IL-10, TNF-a, IL-17A levels were detected by cytometric bead array and clinical information was extracted from medical records. Results. In group IGR and T2DM, we revealed a severe decrease in peripheral ratio of Treg/Th17 compared with NC, but no significant difference was seen in group NGT. The serum level of IL-6 in group NGT and T2DM was higher than healthy subjects. The FPG and HbA1c levels were negatively correlated with the ratio of Treg/Th17 in overweight/obese patients. ROC curve analysis revealed that peripheral Treg/Th17 ratio !1.255 was a risk factor for prediabetes and diabetes in overweight/obese patients. Conclusion. Peripheral Treg/Th17 imbalance exists in overweight/obese patients with IGR or T2DM and peripheral Treg/Th17 imbalance might be a risk factor for prediabetes and diabetes in overweight/obese patients. ? 2020 IMSS. Published by Elsevier Inc.
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