4.6 Article

Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells

Related references

Note: Only part of the references are listed.
Article Toxicology

Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells

Chandrani Fouzder et al.

Summary: The study demonstrated that Trigonelline inhibits Nrf2 activation and its nuclear translocation by blocking the EGFR signaling pathway, enhancing the responsiveness of NSCLC cells to Cisplatin and Etoposide without visible cytotoxicity to normal lung epithelial cells. It showed strong synergism in combination with Cisplatin/Etoposide at lower concentrations than the IC50 values of these drugs, indicating its potential as a promising choice for lung cancer therapy.

TOXICOLOGY IN VITRO (2021)

Article Medicine, General & Internal

Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways

Tung-Wei Hung et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Palmitate induced Fetuin-A secretion from pancreatic β-cells adversely affects its function and elicits inflammation

Alpana Mukhuty et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo

Youyou Qin et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2016)

Article Cell Biology

The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

A. L. Furfaro et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Respiratory System

Prognostic significance of FoxM1 expression in non-small cell lung cancer

Qing Sun et al.

JOURNAL OF THORACIC DISEASE (2016)

Article Biochemistry & Molecular Biology

Dissecting molecular cross-talk between Nrf2 and NF-kappa B response pathways

Joanna D. Wardyn et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Article Biochemistry & Molecular Biology

Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis

Qiang Dang et al.

MOLECULAR CARCINOGENESIS (2015)

Article Biochemistry & Molecular Biology

Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo

Song Chian et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Oncology

Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine

Hong-Quan Duong et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Biochemistry & Molecular Biology

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Durba Pal et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Dongmei Ren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

G. Kroemer et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Dung-Fang Lee et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Xiu Jun Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Pharmacology & Pharmacy

Mechanistic studies of the Nrf2-Keap1 signaling pathway

Donna D. Zhang

DRUG METABOLISM REVIEWS (2006)