Synthesis of nanostructured hardystonite (HT) bioceramic coated on titanium alloy (Ti-6Al-4V) substrate and assessment of its corrosion behavior, bioactivity and cytotoxicity

Bioceramic coatings have had a significant impact on the realm of biomaterials and medical devices in recent decades. In this study, synthesized hardystonite coating (Ca2ZnSi2O7) by sol-gel method was applied on titanium substrate (Ti-6Al-4V) using electrophoretic deposition method. XRD patterns and EDX result confirm the pure hardystonite phase structure. Transmission electron microscopy was confirmed the appeared round morphology and nanometer size of the synthesized hardystonite particles. Additionally SEM analysis was approved that the hardystonite coating is able to make a uniform and flawless apatite with needle-like and cauliflower forms during prolonged exposure to SBF. The Ringer's solution Tafel test results were indicated that the corrosion resistance of twice-coated samples is increased by increasing the voltage to 50 Voltages so that the corrosion current density in the twice coated samples is less than the bare samples. In vitro evaluation by MTT assay was confirmed the viability of the bone marrow stem cells so that hardystonite increases the vitality and reproduction of stem cells at low concentration which makes the hardystonite coating a suitable candidate for clinical applications.

Automated summary

The study synthesized hardystonite coating using sol-gel method, which showed promising properties in terms of structure and biological compatibility in vitro. This suggests that hardystonite coating has potential for clinical applications.