Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 35, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/aoc.6135
Keywords
aryl nitriles; cyanation; K-4[Fe(CN)(6)]· 3H(2)O; Pd@CeO2; visible light irradiation
Categories
Funding
- Analysis Center of Nanjing Tech University
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The study introduces an environmentally friendly and cost-effective method for the cyanation of aryl iodides using a combination of catalyst Pd@CeO2, non-toxic cyanide source, and visible light irradiation. The reaction operates at moderate conditions with high yield and good catalytic efficiency. The catalyst shows good reusability and the reaction system displays tolerance to a wide range of functional groups.
Cyanation of aryl iodides is still challenging work for chemical researchers because of harsh reaction conditions and toxic cyanide sources. Herein, we have developed a new protocol based on the combination of the catalyst Pd@CeO2, nontoxic cyanide source K-4[Fe (CN)(6)]center dot 3H(2)O, and driving force visible light irradiation. The reaction is operated at relatively moderate temperature (55 degrees C) and exhibits good catalytic efficiency of product aryl nitriles (yields of 89.4%). Moreover, the catalyst Pd@CeO2 possesses good reusability with a slight loss of photocatalytic activity after five consecutive runs. The reaction system based on the above combination shows a wide range of functional group tolerance under the same conditions. Reaction conditions such as temperature, time, the component of catalyst, and solutions are optimized by studying cyanation of 1-iodo-4-nitrobenzene as model reaction. According to these results, the possible mechanism of Pd@CeO2-catalyzed cyanation of aryl iodides under visible light irradiation is proposed based on the influence of visible light on the catalyst and reactant compounds. In all, we provided an environmental and economic method for preparation of aryl nitriles from cyanation of aryl iodides based on the goal of green chemistry for sustainable development.
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