Journal
APPLIED OPTICS
Volume 60, Issue 10, Pages B65-B80Publisher
Optica Publishing Group
DOI: 10.1364/AO.416902
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Funding
- Ministry of Science and Technology, Taiwan [108-2221-E-003019-MY3, 109-2811-E-003-500]
- Narodowe Centrum Bada'n i Rozwoju [PLTW/V/5/2018]
- Fundacja na rzecz Nauki Polskiej [TEAM TECH/2016-1/4]
- European RegionalDevelopment Fund
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Holographic tomography is an advanced label-free optical microscopic imaging method used for biological studies, allowing for the recording and reconstruction of a sample's refractive index distribution. The refractive index values are crucial parameters for bio-examination, correlating with metabolic activities and spatial distribution of biophysical parameters of cells and biological objects.
Holographic tomography (HT) is an advanced label-free optical microscopic imaging method used for biological studies. HT uses digital holographic microscopy to record the complex amplitudes of a biological sample as digital holograms and then numerically reconstruct the sample's refractive index (RI) distribution in three dimensions. The RI values are a key parameter for label-free bio-examination, which correlate with metabolic activities and spatiotemporal distribution of biophysical parameters of cells and their internal organelles, tissues, and small-scale biological objects. This article provides insight on this rapidly growing HT field of research and its applications in biology. We present a review summary of the HT principle and highlight recent technical advancement in HT and its applications. (C) 2021 Optical Society of America
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