Journal
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 21, Issue 15, Pages 1957-1976Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520621666210112112422
Keywords
Anticancer agents; azole; secondary metabolites; oncology research; marine sources; natural products
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This review discusses the potential of natural products containing azole nucleus from marine sources in anticancer research, aiming to encourage the scientific community to explore marine resources for developing novel and potent azole-containing anti-cancer agents with better safety profiles.
Background: Despite significant advancement in oncology research, cancer still poses one of the leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole containing medicinal agents are known for plethora of medicinal properties, including anticancer potential. Objective: In this review, we highlighted azole containing natural products with anticancer potential from marine sources. Methods: A comprehensive literature search was performed for writing the review. Updated views about various marine sponges, cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary metabolites with anticancer potential have been discussed. Results: The present article describes the structural, chemical, and biological features of azoles containing natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and future perspectives of azoles in cancer prevention and treatment are also discussed. Conclusion: This review might encourage scientific community to explore marine sources for developing novel and potent azole containing anti-cancer agents with better safety profile.
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