Journal
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
Volume 72, Issue -, Pages 447-458Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-080819-044918
Keywords
cholesterol; coronary artery disease; genetics; inflammation; lipoproteins; triglycerides
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Currently, statins, ezetimibe, and PCSK9 inhibitors are the standard of care for the prevention and treatment of coronary artery disease, but it remains the leading cause of death worldwide. Many new therapies targeting various lipid traits or inflammation have recently received approval or fared favorably in clinical trials, promising to transform the care of patients at risk for life-threatening coronary events.
Statins, ezetimibe, and PCSK9 inhibitors are currently the standard of care for the prevention and treatment of coronary artery disease. Despite their widespread use, coronary artery disease remains the leading cause of death worldwide, a fact that pleads for the development of new protective therapies. In no small part due to advances in the field of human genetics, many new therapies targeting various lipid traits or inflammation have recently received approval from regulatory agencies such as the US Food and Drug Administration or fared favorably in clinical trials. This wave of new therapies promises to transform the care of patients at risk for life-threatening coronary events.
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