Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
Volume 39, Issue -, Pages 131-166Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-061020-053707
Keywords
dendritic cells; Langerhans cells; monocytes; myelopoiesis; adaptive immunity; innate immunity
Categories
Funding
- Francis Crick Institute from Cancer Research UK [FC001136]
- UK Medical Research Council [FC001136]
- Wellcome Trust [FC001136]
- European Research Council Advanced Investigator grant [AdG 268670]
- Wellcome Investigator Award [WT106973MA]
- Boehringer Ingelheim Fonds fellowship
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Dendritic cells play a crucial role in shaping adaptive and innate immunity by integrating environmental information. Conventional DCs, a discrete cell lineage, are highlighted in this review for their key features and impact on other leukocytes.
Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenotypic and functional attributes. We hope that our effort to review the basic features of cDC biology and distinguish cDCs from related cell types brings to the fore the remarkable properties of this cell type while shedding some light on the seemingly inordinate complexity of the DC field.
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