4.7 Article

Nickel(II) complexes of N-CH2CF3 cyclam derivatives as contrast agents for 19F magnetic resonance imaging

Journal

DALTON TRANSACTIONS
Volume 45, Issue 2, Pages 474-478

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5dt04138d

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Funding

  1. Czech Science Foundation [P207-11-1437]
  2. Ministry of Health, Czech Republic [IN00023001]

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Kinetically inert Ni(II) complexes of N-1, N-8-bis(2,2,2-trifluoroethyl) cyclams with hydrogen atoms or phosphonic acid groups in the N-4, N-11-positions show significant F-19 NMR relaxation rate enhancement useful for 19-fluorine MRI imaging.

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