Journal
DALTON TRANSACTIONS
Volume 45, Issue 20, Pages 8355-8366Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6dt01212d
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Funding
- ERC [FCC 266804]
- Royal Society
- Engineering and Physical Sciences Research Council [EP/I010319/1] Funding Source: researchfish
- EPSRC [EP/I010319/1] Funding Source: UKRI
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Two bright, europium(III) complexes based on an achiral heptadentate triazacyclononane ligand bearing two strongly absorbing chromophores have been evaluated for the selective emission and CPL signalling of various chiral O-phosphono-anions. Binding of O-phosphono-Ser and Thr gives rise to a strong induced CPL signature and a favoured. complex configuration is adopted. A similarly large induced CPL signal arises when [Eu.L-1](2+) binds to lysophosphatidic acid (LPA), where the strong binding (log K 5.25 (295 K)) in methanol allowed its detection over the range 5 to 40 mu M. Strong and chemoselective binding to the phosphorylated amino-acid residues was also observed with a set of four structurally related hexa-peptides: in one case, the sign of the g(cm) value in the Delta J = 1 transition allowed differentiation between the binding to O-P-Ser and O-P-Tyr residues.
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