4.5 Article

High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease

Journal

ANNALS OF HEMATOLOGY
Volume 100, Issue 5, Pages 1321-1328

Publisher

SPRINGER
DOI: 10.1007/s00277-020-04347-1

Keywords

Allogeneic hematopoietic stem cell transplantation; Peripheral blood stem cell transplantation; Antithymocyte globulin; Graft-versus-host disease; Absolute lymphocyte count

Categories

Funding

  1. North Japan Hematology Study Group
  2. Japan Agency for Medical Research and Development (AMED) [20ek0510025h0003]

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High absolute lymphocyte counts (ALC) before the administration of antithymocyte globulin (ATG) were significantly associated with severe acute graft-versus-host disease (SC-aGVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT), leading to higher non-relapse mortality (NRM) and worse survival rates.
Antithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We conducted a single-center, retrospective study to analyze the association of acute GVHD requiring systemic corticosteroid (SC-aGVHD) with absolute lymphocyte counts (ALC) before the administration of ATG or conditioning in 53 patients with HLA-matched PBSCT using low-dose thymoglobulin (2 mg/kg) after myeloablative conditioning. The cumulative incidence of SC-aGVHD was 17.0% and ALC before ATG were significantly higher in patients with SC-aGVHD compared to that in patients without it (median, 0.15 x 10(9)/L vs 0.06 x 10(9)/L, P = 0.047). The cumulative incidence of SC-aGVHD was significantly higher in patients with high ALC before ATG (>= 0.15 x 10(9)/L) than in those with low ALC (38.5% vs 10.0%, P = 0.016). Non-relapse mortality (NRM) was also significantly higher in the high ALC before ATG group than the low ALC before ATG group (2-year NRM: 23.9% vs 6.0%, P = 0.048), leading to worse survival (2-year overall survival: 69.2% vs 83.5%, P = 0.039). Our study suggested that high ALC before ATG is a risk factor for SC-aGVHD.

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