Journal
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Volume 126, Issue 3, Pages 240-254Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.anai.2020.11.016
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This article reviews the pathophysiologic mechanisms, differential diagnosis, evaluation, and treatment of ocular allergy, focusing on IgE-mediated disease. Ocular allergies can be IgE or non-IgE mediated, with varying clinical severity that may require a comprehensive treatment regimen tailored to symptom severity.
Objective: The purpose of this article is to review the pathophysiologic mechanisms, differential diagnosis, evaluation, and treatment of the various manifestations of ocular allergy, with an especial focus on immunoglobulin E (IgE)-mediated disease. Data Sources: A PubMed search was performed to include articles, using the search terms ocular allergy and allergic conjunctivitis. Study Selections: Recent and relevant human studies in the English language pertaining to our topic of study were selected. Animal studies pertaining to pathophysiology of ocular allergy were also reviewed. We focused on clinical trials, practice guidelines, reviews, and systematic reviews. In addition, case reports were reviewed if they described rare clinical presentations, disease mechanisms, or novel therapies. Results: Ocular allergy encompasses both IgE-and non-IgE-mediated disease, and the clinical severity may range from mild to sight-threatening inflammation. A comprehensive treatment regimen including education, lifestyle measures, topical therapies, and even systemic interventions may be necessary for the effective management of ocular allergies, tailored according to symptom severity. Conclusion: Ocular allergy is frequently encountered by allergists and eye-care specialists, and despite progressively increasing incidence, it often remains underdiagnosed and, hence, untreated. (C) 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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