Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 12, Pages 6300-6304Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202015979
Keywords
activatable bioimaging; biosensors; cell recognition; DNAzymes; metal ions
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Funding
- NSFC [21822401, 21771044]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- Chinese Academy of Sciences [YJKYYQ20180055, ZDBS-LY-SLH025]
- Young Thousand Talents Program
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Li et al. achieved cell-selective imaging of metal ions using an enzyme-activatable DNAzyme sensor technology, allowing differentiation of metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.
Cell-selective imaging of metal ions was achieved by Lele Li et al. in their Communication (DOI: 10.1002/anie.202015979) by using an enzyme-activatable DNAzyme sensor technology. In the picture, the sensing activity is silent in normal cells and can be restored by an overexpressed enzyme in cancer cells through site-specific cleavage. The DNAzyme sensor allowed to distinguish metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.
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