Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 13, Pages 7275-7282Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202015230
Keywords
arylation of alcohols; cathodic reduction; convergent paired electrolysis; reductive arylation of carbonyls
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Funding
- National Natural Science Foundation of China [21702113, 22071102, 91956110]
- Thousand Talents Plan of Central Plains
- Key Scientific Research Projects of Higher Education Institutions in Henan Province [20A150029]
- National Science Foundation [CHE-1554906]
- Robert A. Welch Foundation [D-1361]
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The electrochemical arylation is an effective method for arylating alcohols, providing structurally diverse alcohols under mild conditions with good functional group tolerance and readily available starting materials. Research also suggests that there are two possible pathways involved in the alpha-arylation of benzylic alcohols.
Arylation of carbonyls, one of the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochemical arylation can fill the gap. By taking advantage of synthetic electrochemistry, commercially available aldehydes (ketones) and benzylic alcohols can be readily arylated to provide a general and scalable access to structurally diverse alcohols (97 examples, >10 gram-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochemical technology, was employed to transform low-value alcohols into more useful alcohols. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral alpha-arylation of benzylic alcohols.
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