Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 8, Pages 4208-4214Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202011513
Keywords
biosensors; contrast agents; peptides; magnetic resonance imaging; nanoparticles
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Funding
- European Union Horizon 2020 research and innovation programme [668119]
- ATTRACT project - EC [777222]
- COST Action (EURELAX) [AC15209]
- Italian Ministry for Education and Research (MIUR)
- EPSRC [EP/K020293/1, EP/E036775/1] Funding Source: UKRI
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This study introduces a novel class of MRI contrast agents with remarkable relaxation effects without the need for paramagnetic metal ions. Image acquisition at variable magnetic field strength is required for their detection using fast field cycling imaging scanners.
This study reports the development of a completely new class of MRI contrast agents, displaying remarkable relaxation effects in the absence of paramagnetic metal ions. Their detection requires the acquisition of images at variable magnetic field strength as provided by fast field cycling imaging scanners. They contain poly-histidine chains (poly-His), whose imidazole groups generate N-14-quadrupolar-peaks that cause a relaxation enhancement of water protons at a frequency (1.38 +/- 0.3 MHz) that is readily detectable from the frequencies associated with endogenous proteins. The poly-His quadrupolar peaks are detectable only when the polymer is in a solid-like form, that is, at pH>6.6. Above this value, their intensity is pH dependent and can be used to report on the occurring pH changes. On this basis, the poly-His moieties were conjugated to biocompatible polymers, such as polylactic and glycolic acid, in order to form stable nanoparticles able to encapsulate structured water in their core. FFC images were acquired to assess their contrast-generating ability.
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