Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 17, Pages 9345-9350Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202015564
Keywords
DNA origami; hybrid frameworks; self-assembly; wireframe
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Funding
- Cryo-EM and Computing Platforms of the Tsinghua University Branch of the National Center for Protein Sciences (Beijing)
- Tsinghua Xuetang Life Science Program
- National Natural Science Foundation of China [31770926]
- Beijing Advanced Innovation Center for Structural Biology
- Tsinghua University-Peking University Joint Center for Life Sciences
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The study introduces a hybrid framework to build wireframe structures, showcasing their simple and versatile design. By combining the construction elements of scaffolded DNA origami approach and scaffold-free LEGO approach, the design space of structural DNA nanotechnology is expanded.
The scaffolded DNA origami approach and the scaffold-free LEGO approach both demonstrate an extraordinary self-assembly capability for constructing all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two-dimensional (2D) and three-dimensional (3D) wireframe structures are presented to showcase the simple and versatile design. Our development reveals more of the ever-expanding design space of structural DNA nanotechnology.
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