Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 10, Pages 5083-5090Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010391
Keywords
cell polarization; ischemic stroke; microglia; nanotechnology; ultrasound
Categories
Funding
- National Natural Science Foundation of China [22034004, 21621003]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- Tsinghua University Spring Breeze Fund [2020Z99CFZ019]
Ask authors/readers for more resources
The study developed a platelet hybrid microglia platform that can polarize to the anti-inflammatory phenotype specifically by ultrasound irradiation for targeted cerebrum repair after stroke, showing promising prospects for stroke therapy.
Stroke is a lethal cerebral disease with severe sequelae and high mortality. Microglia, the main immune cell in the cerebrum, possess therapeutic potential for strokes as its specific anti-inflammatory phenotype can reduce inflammation and promote neuron regeneration. However, the on-demand anti-inflammatory polarization of microglia at the stroke site is uncontrollable for therapeutic application. Here, we develop a platelet hybrid microglia platform which can specifically polarize to the anti-inflammatory phenotype by ultrasound irradiation for targeted cerebrum repair after stroke. The engineered microglia have strong adherence to the injured cerebral vessels with platelet membrane fusion and realize on-demand anti-inflammatory polarization with ultrasound-responsive IL-4 liposome decoration. The intravenously injected microglia platform showed anti-inflammatory polarization at the stroke site with insonation, and accelerated the M2-type polarization of endogenous microglia for long-term stroke recovery. Satisfied prognoses were achieved with reduced apoptosis, promoted neurogenesis, and functional recovery, indicating the implications of the microglia platform for stroke therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available