Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 15, Pages 8391-8395Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202012932
Keywords
alkyne; aniline; axial chirality; indole; rhodium
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Funding
- NSFC [21525208]
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This study reports the rhodium(III)-catalyzed C-H activation of anilines bearing an N-isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C-N reductive elimination constituting the stereo-determining step. The reaction proceeds under mild conditions with high regio- and enantioselectivity and functional group compatibility.
Reported herein is the rhodium(III)-catalyzed C-H activation of anilines bearing an N-isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C-N reductive elimination constituting the stereo-determining step. This reaction proceeds under mild conditions with high regio- and enantioselectivity and functional group compatibility.
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