Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 12, Pages 6724-6732Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202015340
Keywords
continuous-flow microfluidics; dipeptides; microchannel-confined assembly; nanostructures; supramolecular assembly
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Funding
- Federal Ministry of Education and Research (BMBF) [031A360C]
- German Research Foundation (DFG) [1865]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [852065]
- Young Investigator Program of the Technische Universitat Dresden
- National Nature Science Foundation of China [21961142022]
- Alexander vonHumboldt Foundation
- Projekt DEAL
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A simple and precisely controllable method for fabricating dipeptide-based hydrogels through supramolecular assembly inside microfluidic channels is presented in this study. Microfluidically controlled hydrogelation leads to a tailored dipeptide hydrogel with specific material morphology and nanoparticle distribution.
As low-molecular-weight hydrogelators, dipeptide hydrogel materials are suited for embedding multiple organic molecules and inorganic nanoparticles. Herein, a simple but precisely controllable method is presented that enables the fabrication of dipeptide-based hydrogels by supramolecular assembly inside microfluidic channels. Water-soluble quantum dots (QDs) as well as premixed porphyrins and a dipeptide in dimethyl sulfoxide (DMSO) were injected into a Y-shaped microfluidic junction. At the DMSO/water interface, the confined fabrication of a dipeptide-based hydrogel was initiated. Thereafter, the as-formed hydrogel flowed along a meandering microchannel in a continuous fashion, gradually completing gelation and QD entrapment. In contrast to hydrogelation in conventional test tubes, microfluidically controlled hydrogelation led to a tailored dipeptide hydrogel regarding material morphology and nanoparticle distribution.
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