Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 15, Pages 8130-8138Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202014348
Keywords
aggregation; imaging agents; nanoparticles; responsive probes; tumors
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Funding
- National Key Research Program of China [2018YFA0208800]
- NSFC [81530057, 81720108024, 81671754]
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The study introduces an Fe3O4 nanoparticle-based MRI probe that can quantitatively map the heterogeneous distribution of the tumor-specific biomarker GSH in vivo.
Studies reveal that malignant tumors feature uneven distributions of some key biomarkers across the entire tumorous region. Nevertheless, only very limited progress has been made towards non-invasive and quantitative detection of tumor-specific biomarkers in vivo, especially with clinically compatible imaging modalities. Reported here is an Fe3O4 nanoparticle-based glutathione (GSH) responsive magnetic resonance imaging (MRI) probe that can form particle aggregates within tumors in vivo to give rise to strong GSH concentration dependent interlocked relaxivities. A quantitative correlation between the interlocked MRI signals and local GSH concentration was established, and further applied for mapping the heterogeneous distribution of GSH within an intracranial tumor (2.4 mm x 1.6 mm) in vivo. This methodology will offer a practical route for quantitatively mapping tumor-specific biomarkers in vivo with unlimited detection depth, which largely challenges optical-imaging-based approaches.
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