Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 10, Pages 5220-5224Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202012124
Keywords
azobenzene; biomimetic; photochemistry; photochromism; racemase
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Funding
- DST-SERB, Govt. of India [EMR/2017/003720]
- INSPIRE doctoral fellowship by DST-India
- CSIR (Council of Scientific & Industrial Research), India
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This study presents a PLP-photoswitch-imidazole triad that allows the racemization reaction of amino acids to be controlled by light, by adjusting the distance between the basic residue and the reaction center.
The racemase enzymes convert L-amino acids to their D-isomer. The reaction proceeds through a stepwise deprotonation-reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP-photoswitch-imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.
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