Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 10, Pages 5377-5385Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202012916
Keywords
all-DNA nanomedicine; biological production; DNA dendrimers; gene regulation; genetic encoding
Categories
Funding
- National Natural Science Foundation of China [51973089, 31900955, 81702798]
- Shenzhen Fundamental Research Programs [JCYJ20170817105645935, JCYJ20170817105323940]
- Shenzhen Science and Technology Innovation Commission [KQTD20170810111314625, KYTDPT20181011104005]
- Guangdong Innovative Research Team Fund [2016ZT06S172]
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DNA nanomedicines have emerged as potential anti-tumor drugs, with the ability to control the size, shape, and loads of therapeutic motifs. Utilizing DNA nanotechnology, it is possible to genetically encode and produce all-DNA nanomedicines in living bacteria. The biological production capability will enable low-cost, large-scale production and promote clinical applications of all-DNA nanomedicines.
All-DNA nanomedicines have emerged as potential anti-tumor drugs. DNA nanotechnology provides all-DNA nanomedicines with unlimited possibilities in controlling the diversification of size, shape, and loads of the therapeutic motifs. As DNA is a biological polymer, it is possible to genetically encode and produce the all-DNA nanomedicines in living bacteria. Herein, DNA-dendrimer-based nanomedicines are designed to adapt to the biological production, which is constructed by the flexible 3-arm building blocks to enable a highly efficient one-pot DNA assembly. For the first time, a DNA nanomedicine, D4-3-As-DzSur, is successfully genetically encoded, biotechnologically produced, and directly self-assembled. The performance of the biologically produced D4-3-As-DzSur in targeted gene regulation has been confirmed by in vitro and in vivo studies. The biological production capability will fulfill the low-cost and large-scale production of all-DNA nanomedicines and promote clinical applications.
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