Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 19, Pages 10557-10562Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202015596
Keywords
decarboxylation polyfluoroarylation; defluorinative alkylation; late-stage functionalization; photoredox catalysis; radical reaction
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Funding
- MPI fur Kohlenforschung
- Projekt DEAL
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In this study, a novel method for polyfluoroarylation of aliphatic carboxylic acids was reported, with broad substrate scope and high functional group tolerance. Small complex molecules such as natural products and drugs can be modified through late-stage modification.
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late-stage modification.
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