Journal
ANDROLOGIA
Volume 53, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/and.13953
Keywords
idiopathic infertile men; N‐ acetyl‐ cysteine; randomised controlled trials; sperm parameters and serum hormones; systematic review and meta‐ analysis
Categories
Funding
- National Nature Science Foundation of China [81801429] Funding Source: Medline
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20190502] Funding Source: Medline
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201820] Funding Source: Medline
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Oral daily intake of NAC significantly improves sperm parameters in idiopathic infertile men, but does not have a significant impact on serum hormones, requiring more high-quality studies to confirm.
The meta-analysis was performed to access the role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men. Randomised controlled trials (RCTs) were retrieved using PubMed, EMBASE and Cochrane register databases. The references of included studies were also searched. Finally, three articles including 431 infertile men were analysed. The results indicated that the NAC group had a considerable improvement in sperm concentration (mean difference [MD], 3.80; p < .00001), ejaculate volume (MD, 0.69; p = .002), sperm motility (MD, 4.69; p < .0001) and normal morphology (MD, 1.68; p = .0002) compared with the placebo group. However, in terms of serum hormones, the NAC group did not show significant difference in increasing the serum levels of testosterone (MD, 1.35; p = .21), luteinising hormone (MD, 0.82; p = .40), follicle-stimulating hormone (MD, -7.48; p = .29) and prolactin (MD, -0.34; p = .32) compared with the placebo group. In conclusion, NAC orally daily produced a greater improvement in sperm concentration, ejaculate volume, sperm motility and normal morphology for idiopathic infertile men, whereas no significant influence in serum hormones, which required more high-quality RCTs with sufficient sample sizes and statistics to prove.
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