4.7 Article

A new strategy for the preparation of core-shell MOF/Polymer composite material as the mixed-mode stationary phase for hydrophilic interaction/ reversed-phase chromatography

Journal

ANALYTICA CHIMICA ACTA
Volume 1143, Issue -, Pages 181-188

Publisher

ELSEVIER
DOI: 10.1016/j.aca.2020.11.053

Keywords

Core-shell; Chromatographic separation; MOF-235; Polymer-modified stationary phase

Funding

  1. National Natural Science Foundation of China [21575149, 21575148]
  2. State Key Scientific Special Project [2016ZX05011-003]

Ask authors/readers for more resources

The proposed method efficiently synthesized core-shell composite material with superior liquid chromatography performance, particularly in separating nine alkaloids. It provided a general way for preparing MOFs-based composites as mixed-mode chromatographic stationary phases, changing the current status of MOF-based composite materials.
A facile method for efficient synthesis of core-shell composite material was proposed. In this method, the silica microspheres were co-modified with metal organic framework (MOF-235) and polyethylene glycol polymer (PEG) and used as mixed-mode stationary phase (MOE-235@PEG@silica) for high-performance liquid chromatography. Elemental analysis, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and Brunauer-Emmett-Teller etc. methods were used to investigate the properties of the core-shell composite material. The MOF-235@PEG@silica stationary phase showed flexible selectivity for the separation of both hydrophilic and hydrophobic compounds especially for the separation of nine alkaloids, which showed superior hydrophilic separation performance than previous MOF-based composite stationary phases. Some factors including the pH of buffer salt, the ratio of organic phase and water phase in the mobile phase have been investigated, suggesting that the chromatographic retention mechanism of the column was a mixed mode of hydrophilic and reversed phase. The composite material also showed excellent chromatographic repeatability with the RSDs of the retention time found to be 0.2%-0.6% (n = 10) and the standard addition test in the actual sample proved that it can be used for practical sample analysis. In short, it provided a general way for preparing MOFs-based composites as mixed-mode chromatographic stationary phases, and changed the current status of MOF-based composite materials as single mode chromatographic stationary phases. (C) 2020 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available