Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks

Background: The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed. Methods: Using the NCDB, we compared early (14-30 days) and delayed surgery (31-90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death. Results: Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6-73.4), compared to early resection 78.3% (95% CI, 77.9-78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35-41 days (6 weeks), but odds of death increased by 9% per week thereafter. Conclusions: These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks. (C) 2020 Published by Elsevier Inc.

Automated summary

The study found that surgery for early stage colon cancer can be safely delayed up to 6 weeks, with delayed surgery associated with decreased 5-year overall survival. There was no significant increase in the risk of death within 35-41 days of delay.