4.6 Review

Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum in an initial study of subjects with obsessive compulsive disorder

Sean C. Piantadosi et al.

Summary: Studies have found that OCD patients have significantly lower levels of transcripts related to excitatory signaling in both cortical and striatal regions compared to unaffected individuals. While the majority of transcripts encoding excitatory synaptic proteins were lower in OFC, there were no significant differences in the striatum of OCD subjects. These findings suggest a potential upstream causal event in the observed lower levels of multiple glutamatergic transcripts across both medial and lateral OFC.

MOLECULAR PSYCHIATRY (2021)

Article Psychiatry

Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

Jian Xu et al.

Summary: The study found that IgG antibodies from children with PANDAS bound to cholinergic interneurons in the striatum, potentially contributing to the onset of acute OCD symptoms in children. After IVIG treatment, there was a reduction in IgG binding to CINs in PANDAS children's serum, which correlated with symptom improvement.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

Article Neurosciences

Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder

Behrang Mahjani et al.

BIOLOGICAL PSYCHIATRY (2020)

Article Pediatrics

N-Acetylcysteine for Pediatric Obsessive-Compulsive Disorder: A Small Pilot Study

Fenghua Li et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2020)

Article Psychiatry

Cohort profile: Epidemiology and Genetics of Obsessive-compulsive disorder and chronic tic disorders in Sweden (EGOS)

Behrang Mahjani et al.

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY (2020)

Editorial Material Neurosciences

Don't Worry, the Genetics of Obsessive-Compulsive Disorder Is Finally Catching Up

Dorothy E. Grice

BIOLOGICAL PSYCHIATRY (2020)

Review Clinical Neurology

Deep transcranial magnetic stimulation for obsessive compulsive disorder

Alexis G. McCathern et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2020)

Article Multidisciplinary Sciences

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

Ningfei Li et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder

Euripedes C. Miguel et al.

MOLECULAR PSYCHIATRY (2019)

Article Neurosciences

High-dose ondansetron reduces activation of interoceptive and sensorimotor brain regions

Emily R. Stern et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Article Neurosciences

The Case for Adaptive Neuromodulation to Treat Severe Intractable Mental Disorders

Nicole R. Provenza et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Clinical Neurology

Longer-term open-label study of adjunctive riluzole in treatment-resistant depression

Hitoshi Sakurai et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

Review Genetics & Heredity

New insights and perspectives on the genetics of obsessive-compulsive disorder

Gwyneth Zai et al.

PSYCHIATRIC GENETICS (2019)

Review Pharmacology & Pharmacy

The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder

Angelica P. Escobar et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Anatomy & Morphology

Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder

Katia Cristina de Oliveira et al.

BRAIN STRUCTURE & FUNCTION (2019)

Article Psychology, Clinical

Augmentation With Memantine in Obsessive-Compulsive Disorder

Chittaranjan Andrade

JOURNAL OF CLINICAL PSYCHIATRY (2019)

Article Biochemistry & Molecular Biology

Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis

Paul D. Arnold et al.

MOLECULAR PSYCHIATRY (2018)

Article Psychology, Clinical

FEAR CONDITIONING AND EXTINCTION IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER

Joseph F. McGuire et al.

DEPRESSION AND ANXIETY (2016)

Article Psychology, Developmental

Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections

Kyle A. Williams et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2016)

Article Psychiatry

Mortality Among Persons With Obsessive-Compulsive Disorder in Denmark

Sandra M. Meier et al.

JAMA PSYCHIATRY (2016)

Article Psychiatry

Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders

Ashley E. Nordsletten et al.

JAMA PSYCHIATRY (2016)

Review Psychiatry

The Clinical Discovery of Imipramine

Walter A. Brown et al.

AMERICAN JOURNAL OF PSYCHIATRY (2015)

Review Psychology, Clinical

DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS

Susanne E. Ahmari et al.

DEPRESSION AND ANXIETY (2015)

Article Pediatrics

Characterization of the Pediatric Acute-Onset Neuropsychiatric Syndrome Phenotype

Tanya K. Murphy et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2015)

Article Psychology, Clinical

Riluzole Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder: A Pilot Randomized Placebo-Controlled Trial

Christopher Pittenger et al.

JOURNAL OF CLINICAL PSYCHIATRY (2015)

Article Neurosciences

From the neuron doctrine to neural networks

Rafael Yuste

NATURE REVIEWS NEUROSCIENCE (2015)

Review Behavioral Sciences

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

Deepmala et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2015)

Article Biochemistry & Molecular Biology

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

M. Mattheisen et al.

MOLECULAR PSYCHIATRY (2015)

Article Neurosciences

Precuneus Is a Functional Core of the Default-Mode Network

Amanda V. Utevsky et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Psychology, Developmental

Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Lauren M. McGrath et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2014)

Review Neurosciences

Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective

David L. Pauls et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Article Psychiatry

Cognitive Neuroscience of Obsessive-Compulsive Disorder

Emily R. Stern et al.

PSYCHIATRIC CLINICS OF NORTH AMERICA (2014)

Article Psychiatry

Pharmacological Treatment of Obsessive-Compulsive Disorder

Christopher Pittenger et al.

PSYCHIATRIC CLINICS OF NORTH AMERICA (2014)

Article Genetics & Heredity

Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

S. E. Stewart et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2013)

Review Neurosciences

A Critical Review of Magnetic Resonance Spectroscopy Studies of Obsessive-Compulsive Disorder

Brian P. Brennan et al.

BIOLOGICAL PSYCHIATRY (2013)

Article Endocrinology & Metabolism

Metabolic imaging of bilateral anterior capsulotomy in refractory obsessive compulsive disorder: an FDG PET study

ChuanTao Zuo et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

Article Biochemistry & Molecular Biology

Genome-wide association study of obsessive-compulsive disorder

S. E. Stewart et al.

MOLECULAR PSYCHIATRY (2013)

Article Neurosciences

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

Carolyn I. Rodriguez et al.

NEUROPSYCHOPHARMACOLOGY (2013)

Article Multidisciplinary Sciences

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Susanne E. Ahmari et al.

SCIENCE (2013)

Article Clinical Neurology

Lesion Procedures in Psychiatric Neurosurgery

Shaun R. Patel et al.

WORLD NEUROSURGERY (2013)

Review Medicine, Research & Experimental

Deep Brain Stimulation for Intractable Psychiatric Disorders

Wayne K. Goodman et al.

ANNUAL REVIEW OF MEDICINE, VOL 63 (2012)

Article Neurosciences

Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder

Michael H. Bloch et al.

BIOLOGICAL PSYCHIATRY (2012)

Article Biochemistry & Molecular Biology

Another view of the history of antipsychotic drug discovery and development

W. T. Carpenter et al.

MOLECULAR PSYCHIATRY (2012)

Review Genetics & Heredity

DISEASE MECHANISMS Genetic architectures of psychiatric disorders: the emerging picture and its implications

Patrick F. Sullivan et al.

NATURE REVIEWS GENETICS (2012)

Article Psychiatry

Obsessive-compulsive disorder in the community: 12-month prevalence, comorbidity and impairment

Yuki Adam et al.

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY (2012)

Review Behavioral Sciences

Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways

Mohammed R. Milad et al.

TRENDS IN COGNITIVE SCIENCES (2012)

Review Psychiatry

A review of obsessive intrusive thoughts in the general population

Lisa-Marie Berry et al.

JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS (2012)

Review Behavioral Sciences

Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits

Sarah K. Bourne et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2012)

Article Pharmacology & Pharmacy

Sarcosine Therapy for Obsessive Compulsive Disorder A Prospective, Open-Label Study

Po-Lun Wu et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2011)

Article Pediatrics

Functional Magnetic Resonance Imaging During Planning Before and After Cognitive-Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder

Chaim Huyser et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2011)

Article Psychology, Developmental

Developmental Alterations of Frontal-Striatal-Thalamic Connectivity in Obsessive-Compulsive Disorder

Kate Dimond Fitzgerald et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2011)

Review Pharmacology & Pharmacy

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

Christopher Pittenger et al.

PHARMACOLOGY & THERAPEUTICS (2011)

Review Psychology, Clinical

Early versus late onset obsessive-compulsive disorder: Evidence for distinct subtypes

Steven Taylor

CLINICAL PSYCHOLOGY REVIEW (2011)

Article Pharmacology & Pharmacy

A Single-Blinded Case-Control Study of Memantine in Severe Obsessive-Compulsive Disorder

S. Evelyn Stewart et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication

A. M. Ruscio et al.

MOLECULAR PSYCHIATRY (2010)

Review Neurosciences

Invasive Circuitry-Based Neurotherapeutics: Stereotactic Ablation and Deep Brain Stimulation for OCD

Benjamin D. Greenberg et al.

NEUROPSYCHOPHARMACOLOGY (2010)

Review Neurosciences

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Suzanne N. Haber et al.

NEUROPSYCHOPHARMACOLOGY (2010)

Article Genetics & Heredity

Sapap3 and Pathological Grooming in Humans: Results From the OCD Collaborative Genetics Study

O. J. Bienvenu et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2009)

Article Psychiatry

Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder

Ben J. Harrison et al.

ARCHIVES OF GENERAL PSYCHIATRY (2009)

Editorial Material Neurosciences

Deep Brain Stimulation in Psychiatry: Concentrating on the Road Ahead

Wayne K. Goodman et al.

BIOLOGICAL PSYCHIATRY (2009)

Article Psychiatry

Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults

William M. Greenberg et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2009)

Review Medicine, General & Internal

Obsessive-compulsive disorder

Jonathan S. Abramowitz et al.

LANCET (2009)

Article Neurosciences

Anti-Brain Autoantibodies and Altered Excitatory Neurotransmitters in Obsessive-Compulsive Disorder

Sagnik Bhattacharyya et al.

NEUROPSYCHOPHARMACOLOGY (2009)

Article Clinical Neurology

Changes after behavior therapy among responsive and nonresponsive patients with obsessive-compulsive disorder

Tomoaki Yamanishi et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2009)

Article Multidisciplinary Sciences

Optical Deconstruction of Parkinsonian Neural Circuitry

Viviana Gradinaru et al.

SCIENCE (2009)

Review Biochemistry & Molecular Biology

Mechanisms of fear extinction

K. M. Myers et al.

MOLECULAR PSYCHIATRY (2007)

Article Psychiatry

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Carlos A. Zarate et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

Review Biochemistry & Molecular Biology

A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder

M. H. Bloch et al.

MOLECULAR PSYCHIATRY (2006)

Article Psychology, Clinical

Response versus remission in obsessive-compulsive disorder

HB Simpson et al.

JOURNAL OF CLINICAL PSYCHIATRY (2006)

Article Neurosciences

Glutamatergic dysfunction in OCD

K Chakrabarty et al.

NEUROPSYCHOPHARMACOLOGY (2005)

Article Neurosciences

Obsessive-compulsive symptoms among patients with sydenham chorea

FR Asbahr et al.

BIOLOGICAL PSYCHIATRY (2005)

Article Neurosciences

Deep brain stimulation for refractory obsessive-compulsive disorder

JL Abelson et al.

BIOLOGICAL PSYCHIATRY (2005)

Review Psychology, Clinical

Cognitive and behavioral treatments for anxiety disorders: A review of meta-analytic finding

BJ Deacon et al.

JOURNAL OF CLINICAL PSYCHOLOGY (2004)

Article Clinical Neurology

Obsessive-compulsive disorder after unilateral caudate nucleus bleeding

S Thobois et al.

ACTA NEUROCHIRURGICA (2004)

Article Psychology, Clinical

Sympathetic magic in contamination-related OCD

DF Tolin et al.

JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY (2004)

Article Psychiatry

Obsessive-compulsive disorder after traumatic brain injury

MA Grados

INTERNATIONAL REVIEW OF PSYCHIATRY (2003)

Article Pharmacology & Pharmacy

Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder

DL Ackerman et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2002)

Article Psychiatry

Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder

S Saxena et al.

PSYCHIATRIC CLINICS OF NORTH AMERICA (2000)