Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 320, Issue 1, Pages E131-E138Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00175.2020
Keywords
adenosine deaminase acting on RNA 1; appetite; insulin resistance; obesity
Categories
Funding
- National Institutes of Health [HL123302, HL119053, HL135854, HL147313]
- AHA Scientist Development Grant [17SDG32790003]
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This study identifies adenosine deaminase acting on RNA 1 as a novel factor promoting high-fat diet induced obesity, at least partially, through modulating appetite-related genes ghrelin and PYY.
Obesity is an important independent risk factor for type 2 diabetes, cardiovascular diseases, and many other chronic diseases. The objective of this study was to determine the role of adenosine deaminase acting on RNA 1 (ADAR1) in the development of obesity and insulin resistance. Wild-type (WT) and heterozygous ADAR1-deficient (Adar1(+/-)) mice were fed normal chow or a high-fat diet (HFD) for 12 wk. Adar1(+/-) mice fed with HFD exhibited a lean phenotype with reduced fat mass compared with WT controls, although no difference was found under chow diet conditions. Blood biochemical analysis and insulin tolerance test showed that Adar1(+/-) improved HFD-induced dyslipidemia and insulin resistance. Metabolic studies showed that food intake was decreased in Adar1(+/-) mice compared with the WT mice under HFD conditions. Paired feeding studies further demonstrated that Adar1(+/-) protected mice from HFD-induced obesity through decreased food intake. Furthermore, Adar1(+/-) restored the increased ghrelin expression in the stomach and the decreased serum peptide YY levels under HFD conditions. These data indicate that ADAR1 may contribute to diet-induced obesity, at least partially, through modulating the ghrelin and peptide YY expression and secretion. NEW & NOTEWORTHY This study identifies adenosine deaminase acting on RNA 1 as a novel factor promoting high-fat diet induced obesity, at least partially, through modulating appetite-related genes ghrelin and PYY.
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