Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 96, Issue 3, Pages 367-378Publisher
WILEY
DOI: 10.1002/ajh.26080
Keywords
-
Categories
Ask authors/readers for more resources
The introduction of novel agents has rapidly expanded the therapeutic landscape of multiple myeloma (MM), with the assessment of minimal residual disease (MRD) serving as a powerful predictor of long-term outcomes and providing opportunities for personalized treatment approaches.
The introduction of novel agents over the last decade has rapidly expanded the therapeutic landscape of multiple myeloma (MM) for both transplant-eligible and transplant-ineligible patients. The assessment of minimal residual disease (MRD) by next-generation flow cytometry or next-generation sequencing is established as a powerful predictor of long-term outcomes. The use of MRD in response-adapted clinical trials may provide opportunities to identify candidates for treatment escalation and de-escalation. Agents with proven activity in the relapsed and refractory setting are being studied in the management of high-risk newly diagnosed MM (NDMM). Here, we summarize the most recent clinical trials that have led to the current paradigms in the management of NDMM. We also discuss how novel agents could be incorporated in the newly diagnosed setting and potential clinical trial designs that could leverage MRD information with the goal of treatment optimization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available