Journal
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 116, Issue 5, Pages 1077-1082Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.14309/ajg.0000000000001154
Keywords
-
Categories
Ask authors/readers for more resources
This study discusses three cases of patients recovering from critical cardiopulmonary COVID-19 who developed prolonged and severe cholestasis, with histologic features similar to secondary sclerosing cholangitis but also unique characteristics indicating direct hepatic injury from COVID-19. These cases suggest a novel severe post-COVID-19 cholangiopathy with potential for long-term hepatic morbidity.
INTRODUCTION: Liver chemistry abnormalities are a frequent manifestation of coronavirus disease 2019 (COVID-19) but are usually transient and resolve with disease resolution. METHODS: We describe the clinical course and histologic features of 3 adults who developed prolonged and severe cholestasis during recovery from critical cardiopulmonary COVID-19. RESULTS: These patients had clinical and histologic features similar to secondary sclerosing cholangitis of the critically ill patient, but with unique histologic features including severe cholangiocyte injury and intrahepatic microangiopathy suggestive of direct hepatic injury from COVID-19. DISCUSSION: We believe that these cases constitute a novel severe post-COVID-19 cholangiopathy with potential for long-term hepatic morbidity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available