Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 49, Issue 1, Pages 181-198Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500105
Keywords
Gossypol; Metastasis; Invasion; Epithelial-Mesenchymal Transition; Cervical Cancer
Funding
- Ministry of Science and Technology, Taiwan [MOST 103-2313-B-040-003-MY3, MOST 109-2320-B-040-015]
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The research showed that gossypol inhibited the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT.
Metastasis is the most prevalent cause of cancer-associated deaths amongst patients with cervical cancer. Epithelial-mesenchymal transition (EMT) is essential for carcinogenesis, and it confers metastatic properties to cancer cells. Gossypol is a natural polyphenolic compound with anti-inflammation, anti-oxidant, and anticancer activities. In this study, we investigated the antimetastatic and antitumour effects of gossypol on human cervical cancer cells (HeLa and SiHa cells). Gossypol exerted a strong inhibition effect on the migration and invasion of human cervical cancer cells. It reduced the focal adhesion kinase (FAK) pathway-mediated expression of matrix metalloproteinase-2 and urokinase-type plasminogen activator, subsequently inhibiting the invasion of SiHa cells. In addition, gossypol reversed EMT induced by transforming growth factor beta 1 (TGF-beta 1) and up-regulated epithelial markers, such as E-cadherin but significantly suppressed Ras homolog family member (Rho)A, RhoB, and p-Samd3. The tail vein injection model showed that gossypol treatment via oral gavage reduced lung metastasis. Gossypol also decreased tumour growth in vivo in the nude mouse xenograft model. All these findings suggest that gossypol suppressed the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT. Hence, gossypol warrants further attention for basic mechanistic studies and drug development.
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