Journal
AIDS
Volume 35, Issue 3, Pages 359-367Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000002753
Keywords
ApoL1; HIV-1; HIV-associated nephropathy; kidney disease; kidney transplantation; reservoir; urine
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [P01DK056492, R01DK108367]
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People living with HIV are at higher risk for acute and chronic kidney disease compared with uninfected individuals. Kidney disease in this population is multifactorial, with several contributors including HIV infection of kidney cells. Research has shown that direct HIV infection can impact renal cells.
People living with HIV are at higher risk for acute and chronic kidney disease compared with uninfected individuals. Kidney disease in this population is multifactorial, with several contributors including HIV infection of kidney cells, chronic inflammation, genetic predisposition, aging, comorbidities, and coinfections. In this review, we provide a summary of recent advancements in the understanding of the mechanisms and implications of HIV infection and kidney disease, with particular focus on the role of direct HIV infection of renal cells.
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