4.6 Article

Development of prognostic signature based on RNA binding proteins related genes analysis in clear cell renal cell carcinoma

Journal

AGING-US
Volume 13, Issue 3, Pages 3926-3944

Publisher

IMPACT JOURNALS LLC
DOI: 10.18632/aging.202360

Keywords

clear cell renal cell carcinoma; RNA binding proteins; biomarker; prognostic model

Funding

  1. National Natural Science Foundation of China (NSFC) [81460137]
  2. Natural Science Foundation of Jiangxi [20151BAB205015]
  3. Special Fund for Postgraduate Innovation of Nanchang University [CX2018183]

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This study successfully predicted the prognosis of ccRCC patients by constructing a risk model related to RNA binding proteins, providing convenience for the identification of novel diagnostic and prognostic molecular markers.
RNA binding proteins (RBPs) play significant roles in the development of tumors. However, a comprehensive analysis of the biological functions of RBPs in clear cell renal cell carcinoma (ccRCC) has not been performed. Our study aimed to construct an RBP-related risk model for prognosis prediction in ccRCC patients. First, RNA sequencing data of ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database. Three RBP genes (EIF4A1, CARS, and RPL22L1) were validated as prognosis-related hub genes by univariate and multivariate Cox regression analyses and were integrated into a prognostic model by least absolute shrinkage and selection operator (LASSO) Cox regression analysis. According to this model, patients with high risk scores displayed significantly worse overall survival (OS) than those with low risk scores. Moreover, the multivariate Cox analysis results indicated that risk score, tumor grade, and tumor stage were significantly correlated with patient OS. A nomogram was constructed based on the three RBP genes and showed a good ability to predict outcomes in ccRCC patients. In conclusion, this study identified a three-RBP gene risk model for predicting the prognosis of patients, which is conducive to the identification of novel diagnostic and prognostic molecular markers.

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