4.7 Article

Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice

Related references

Note: Only part of the references are listed.
Article Cell Biology

Single-cell transcriptomic atlas of primate cardiopulmonary aging

Shuai Ma et al.

Summary: The research indicates that aging is associated with increased systemic inflammation and compromised virus defense in the cardiopulmonary system. With age, expression of the SARS-CoV-2 receptor ACE2 increases, while the accumulation of the cytokine IL7 induces ACE2 expression. Treatment with vitamin C can block IL7-induced ACE2 expression, suggesting that geroprotective strategies may reduce the severity of COVID-19 in the elderly.

CELL RESEARCH (2021)

Article Cell Biology

A Single-Cell Transcriptomic Atlas of Human Skin Aging

Zhiran Zou et al.

Summary: Single-cell RNA sequencing of human eyelid skin revealed progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process showed early-onset decline during aging. Inhibition of key transcription factors HES1 and KLF6 compromised cell proliferation, increased inflammation, and accelerated cellular senescence during aging.

DEVELOPMENTAL CELL (2021)

Review Endocrinology & Metabolism

Mitochondrial Dysfunction and Ovarian Aging

Isil Kasapoglu et al.

ENDOCRINOLOGY (2020)

Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging

Qingling Yang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Cell & Tissue Engineering

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

Cindy T. J. van Velthoven et al.

CELL STEM CELL (2019)

Letter Cell Biology

Characterization of oogonia stem cells in mice by Fragilis

Xiaoyan Sheng et al.

PROTEIN & CELL (2019)

Article Multidisciplinary Sciences

Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function

Antoine de Morree et al.

SCIENCE (2019)

Review Biochemistry & Molecular Biology

Retinoic Acid and Germ Cell Development in the Ovary and Testis

Tsutomu Endo et al.

BIOMOLECULES (2019)

Article Cell Biology

Functional Oocytes Derived from Granulosa Cells

Chenglei Tian et al.

CELL REPORTS (2019)

Article Biochemistry & Molecular Biology

mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus

Xiaojing Li et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)

Review Developmental Biology

The role of mitochondria in stem cell fate and aging

Hongbo Zhang et al.

DEVELOPMENT (2018)

Article Multidisciplinary Sciences

Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

Jing Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Obstetrics & Gynecology

The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights

Gustavo Nardini Cecchino et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2018)

Article Cell Biology

Inhibition of mTOR Signaling Pathway Delays Follicle Formation in Mice

Jing Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

Article Geriatrics & Gerontology

Targeting chromatin aging - The epigenetic impact of longevity-associated interventions

Adam E. Field et al.

EXPERIMENTAL GERONTOLOGY (2017)

Article Obstetrics & Gynecology

The role of ovarian reserve markers in prediction of clinical pregnancy

Ali G. Zebitay et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2017)

Article Multidisciplinary Sciences

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

Kara N. Goldman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Reconstitution of ovarian function following transplantation of primordial germ cells

Ming Zeng et al.

SCIENTIFIC REPORTS (2017)

Article Cell & Tissue Engineering

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

Samantha Haller et al.

CELL STEM CELL (2017)

Review Cell Biology

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ruotong Ren et al.

CELL METABOLISM (2017)

Article Biochemistry & Molecular Biology

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

Sarah E. Calvo et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Cell Biology

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

Brian K. Kennedy et al.

CELL METABOLISM (2016)

Review Cell & Tissue Engineering

Gametogenesis from Pluripotent Stem Cells

Mitinori Saitou et al.

CELL STEM CELL (2016)

Article Obstetrics & Gynecology

Ovarian ageing: the role of mitochondria in oocytes and follicles

Pascale May-Panloup et al.

HUMAN REPRODUCTION UPDATE (2016)

Article Multidisciplinary Sciences

Reconstitution in vitro of the entire cycle of the mouse female germ line

Orie Hikabe et al.

NATURE (2016)

Article Obstetrics & Gynecology

Telomeres, Reproductive Aging, and Genomic Instability During Early Development

David L. Keefe

REPRODUCTIVE SCIENCES (2016)

Review Cell Biology

Interventions to Slow Aging in Humans: Are We Ready?

Valter D. Longo et al.

AGING CELL (2015)

Review Cell & Tissue Engineering

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

Peter D. Adams et al.

CELL STEM CELL (2015)

Editorial Material Genetics & Heredity

Diminished ovarian reserve, premature ovarian failure, poor ovarian responder-a plea for universal definitions

J. Cohen et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

Article Biochemical Research Methods

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim et al.

NATURE METHODS (2015)

Article Multidisciplinary Sciences

Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis

Tsutomu Endo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Obstetrics & Gynecology

Metabolic Determinants of Mitochondrial Function in Oocytes

Emily A. Seidler et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Reproductive Biology

Generation of Mouse Functional Oocytes in Rat by Xeno-Ectopic Transplantation of Primordial Germ Cells

Tomonari Hayama et al.

BIOLOGY OF REPRODUCTION (2014)

Article Obstetrics & Gynecology

Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure

Yingying Qin et al.

FERTILITY AND STERILITY (2014)

Article Multidisciplinary Sciences

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Joseph T. Rodgers et al.

NATURE (2014)

Article Multidisciplinary Sciences

Interleukin-1 deficiency prolongs ovarian lifespan in mice

Shiri Uri-Belapolsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell & Tissue Engineering

FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

Suchitra D. Gopinath et al.

STEM CELL REPORTS (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Geriatrics & Gerontology

Regulation of longevity by the reproductive system

Adam Antebi

EXPERIMENTAL GERONTOLOGY (2013)

Article Obstetrics & Gynecology

Resveratrol protects against age-associated infertility in mice

Mengyuan Liu et al.

HUMAN REPRODUCTION (2013)

Review Medicine, Research & Experimental

Coming of age: molecular drivers of aging and therapeutic opportunities

Christopher B. Newgard et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Multidisciplinary Sciences

mTOR is a key modulator of ageing and age-related disease

Simon C. Johnson et al.

NATURE (2013)

Review Cell Biology

Molecular regulation of stem cell quiescence

Tom H. Cheung et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles

Lei Lei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Obstetrics & Gynecology

Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure

Zhiyi Zhao et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2013)

Article Cell & Tissue Engineering

Recovery of Functional Oocytes from Cultured Premeiotic Germ Cells After Kidney Capsule Transplantation

Bo Chen et al.

STEM CELLS AND DEVELOPMENT (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Editorial Material Biochemistry & Molecular Biology

The quest for human ovarian stem cells

Evelyn E. Telfer et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries

Hua Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice

Katsuhiko Hayashi et al.

SCIENCE (2012)

Review Biology

An update on primary ovarian insufficiency

Jin Min et al.

SCIENCE CHINA-LIFE SCIENCES (2012)

Article Obstetrics & Gynecology

Cardiovascular disease and ovarian function

Amanda N. Kallen et al.

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2011)

Article Obstetrics & Gynecology

The Menopausal Transition and Cardiovascular Risk

Claudia U. Chae et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2011)

Article Endocrinology & Metabolism

Premature ovarian failure and FMR1 gene mutations: An update

G. S. Conway

ANNALES D ENDOCRINOLOGIE (2010)

Article Biochemistry & Molecular Biology

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

Deepak Adhikari et al.

HUMAN MOLECULAR GENETICS (2010)

Review Endocrinology & Metabolism

Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles

Deepak Adhikari et al.

ENDOCRINE REVIEWS (2009)

Review Developmental Biology

The primordial pool of follicles and nest breakdown in mammalian ovaries

Candace Tingen et al.

MOLECULAR HUMAN REPRODUCTION (2009)

Article Multidisciplinary Sciences

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison et al.

NATURE (2009)

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

Article Biochemistry & Molecular Biology

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini et al.

Article Multidisciplinary Sciences

Germ Cell-Intrinsic and -Extrinsic Factors Govern Meiotic Initiation in Mouse Embryos

Yanfeng Lin et al.

SCIENCE (2008)

Article Obstetrics & Gynecology

Mature oocytes derived from purified mouse fetal germ cells

Tingting Qing et al.

HUMAN REPRODUCTION (2008)

Article Immunology

Immune physiology of the mammalian ovary - A review

Antonin Bukovsky et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2008)

Review Biochemistry & Molecular Biology

Genetic and epigenetic regulators of pluripotency

M. Azim Surani et al.

Review Endocrinology & Metabolism

Female reproductive ageing: current knowledge and future trends

Frank J. Broekmans et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2007)

Review Oncology

Reproductive ageing in women

O. Djahanbakhch et al.

JOURNAL OF PATHOLOGY (2007)

Article Reproductive Biology

Live offspring produced by mouse oocytes derived from premeiotic fetal germ cells

Wei Shen et al.

BIOLOGY OF REPRODUCTION (2006)

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

S Wullschleger et al.

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

Stephan Wullschleger et al.

Article Developmental Biology

Methods for quantifying follicular numbers within the mouse ovary

M Myers et al.

REPRODUCTION (2004)

Review Obstetrics & Gynecology

The variability of female reproductive ageing

ERT Velde et al.

HUMAN REPRODUCTION UPDATE (2002)