Journal
AGEING RESEARCH REVIEWS
Volume 64, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2020.101154
Keywords
DNA repair; Aging; Senescence; Inflammation; Rejuvenation; DNA repair reporter cassette
Categories
Funding
- National Key R&D Program of China [2018YFC2000100, 2017YFA0103300]
- National Natural Science Foundation of China [31871438, 81972457]
- Shu Guang project - Shanghai Municipal Education Commission [19SG18]
- Shanghai Education Development Foundation [19SG18]
- Program of Shanghai Academic Research Leader [19XD1403000]
- Shanghai municipal medical and health discipline construction projects [2017ZZ02015]
- Fundamental Research Funds for the Central Universities
- Open Project Program of State Key Laboratory of Natural Medicines [SKLNMKF201905]
Ask authors/readers for more resources
DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
