Journal
DALTON TRANSACTIONS
Volume 45, Issue 30, Pages 11926-11930Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6dt01571a
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Funding
- Portuguese Foundation for Science and Technology (FCT) [PTDC/QUI-QUI/102114/2008, PTDC/QUI-QUI/110532/2009, UID/QUI/00100/2013, UID/MULTI/00612/2013]
- FCT [SFRH/BD/96517/2013, IF/00849/2012, IF/00069/2014]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-QUI/102114/2008, SFRH/BD/96517/2013, PTDC/QUI-QUI/110532/2009] Funding Source: FCT
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Eight ruthenium(n) compounds of the general formula [(eta(5)-C5H5)Ru(N-N)(PPh3)][PF6] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 mu M; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.
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