4.7 Article

Synthesis of Indolo[2,1-a]isoquinolin-6(5H)-Ones Derivatives via Fe(OTf)3-Promoted Tandem Selenylation/Cyclization of 2-Arylindoles

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 363, Issue 2, Pages 497-504

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000983

Keywords

2-arylindoles; diselenides; Fe(OTf)(3)-promoted; indolo[2,1-a]isoquinolin-6(5H)-ones; selenylation

Funding

  1. National Natural Science Foundation of China [21861015]
  2. Guangxi Science and Technology Base and Talents Program [AD18281035, AD18281028]
  3. Cultivation Plan of Thousands of Young and Middle-aged Backbone Teachers in Guangxi Colleges and Universities

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A practical method for the synthesis of selenylsubstituted indolo[2,1-a]isoquinolin-6(5H)-ones was developed through Fe(OTf)(3)-promoted tandem selenylation/cyclization of 2-arylindoles, forming new C-Se and C-C bonds simultaneously under mild conditions.
A practical method for the synthesis of selenylsubstituted indolo[2,1-a]isoquinolin-6(5H)-ones through Fe(OTf)(3)-promoted tandem selenylation/cyclization of 2-arylindoles was developed. In this transformation, new C-Se bond and C-C bond were constructed simultaneously under mild conditions.

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