Visible-Light-Induced Three-Component Intermolecular Trifluoromethyl-Alkenylation Reactions of Unactivated Alkenes

Herein, we describe a practical protocol for efficient, mild, visible-light-induced three-component intermolecular trifluoromethyl-alkenylation reactions of unactivated alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this protocol, we not only introduced a trifluoromethyl group into alkenes but also converted unactivated alkenes to styrene-based activated alkenes, in addition to accomplishing late-stage functionalization of pharmaceutical intermediates.

Automated summary

The practical protocol described utilizes visible-light induction for efficient and mild three-component intermolecular trifluoromethyl-alkenylation reactions of unactivated alkenes. It demonstrates good functional group tolerance and a wide substrate scope, allowing for introduction of trifluoromethyl groups, conversion of unactivated alkenes to styrene-based activated alkenes, and late-stage functionalization of pharmaceutical intermediates.