Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 363, Issue 4, Pages 1105-1111Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202001250
Keywords
Metalla photoredox catalysis; Cobalt; Allylation; Aldehydes; Iridium(III) photocatalyst
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Funding
- National PRIN [20174SYJAF, 20172M3K5N]
- University of Alicante (Spain)
- Paris Tech (France)
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The study demonstrates that under photoredox catalysis, allylation of aldehydes using organometallic cobalt species can be achieved without the need for stoichiometric amounts of zinc. The reaction proceeds in moderate to good yields under specific conditions.
The preparation of homoallylic alcohols by addition of organometallic allyl compounds to carbonyls is an important strategy in organic chemistry. Allylating organometallic cobalt species can be generated employing stoichiometric quantities of Zn acting as reductant. To avoid the employment of stoichiometric amount of Zn, we have developed an allylation reaction of aromatic and aliphatic aldehydes promoted by photoredox catalysis in the presence of a cobalt complex, and we present herein a full account of our research. In the presence of the abundant CoBr2 (10 mol %), 4,4 '-di-tert-butyl-2,2 '-dipyridyl (dtbbpy, 10 mol %), allyl acetate (3 equiv.), [Ir(dtbbpy)(ppy)(2)]PF6 (ppy=2-phenylpyridine, 2 mol %), and N,N-diisopropylethylamine (4 equiv.), an allylation of aldehydes is taking place, in moderate to good yields. Substrates scope, limitations, and photophysical investigations of this new process are reported.
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