Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202010388
Keywords
integrated sensors; microfluidics; non‐ invasive diagnostics; point‐ of‐ care testing; wearables
Categories
Funding
- German Research Foundation (DFG) [404478562, 421356369, 397660978]
- CERCA programme/Generalitat de Catalunya
- Severo Ochoa Centres of Excellence programme
- Spanish Research Agency (AEI) [SEV-2017-0706]
- MINECO Project [MAT2017-87202-P]
- Projekt DEAL
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Integrated diagnostic devices are recognized as the ultimate solution to simplify healthcare testing, accelerating intervention and improving patient outcomes. The combination of non-invasive sampling and integrated devices is of substantial interest for improving patient comfort and safety. Factors affecting the transition of integrated devices from academia to market, such as technology readiness levels and survival rates, are crucial for success.
Sample-in-answer-out type integrated diagnostic devices have been widely recognized as the ultimate solution to simplify testing across healthcare systems. Such systems are equipped with advanced fluidic, mechanical, chemical, biological, and electronic components to handle patient samples without any manual steps therefore have the potential to accelerate intervention and improve patient outcomes. In this regard, the combination of integrated devices and non-invasive sampling has gained a substantial interest to further improve the comfort and safety of patients. In this Review, the pioneering developments in integrated diagnostics are covered and their potential in non-invasive sampling is discussed. The key properties of possible sample types are highlighted by addressing their relevance for the clinical practice. Last, the factors affecting the transition of integrated devices from academia to the market are identified by analyzing the technology readiness levels of selected examples and alternative remedies are explored to increase the rate of survival during this transition.
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