Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202009431
Keywords
adhesiolysis; anti‐ adhesion materials; cream gel; postoperative adhesion; zwitterionic material
Categories
Funding
- Wayne State University
- National Science Foundation [1410853, 1809229]
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [DP2DK111910, R01DK123293]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1809229, 1410853] Funding Source: National Science Foundation
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Postoperative peritoneal adhesions are common complications that lead to medical problems and financial burden. Current anti-adhesion strategies focus on physical barriers, but a new biodegradable zwitterionic cream gel has shown promising results in preventing adhesions in animal models.
Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti-adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti-adhesion material, including unique injectable yet malleable and self-supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein/cell resistance, and biodegradability. The cream gel shows a major advancement in anti-adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.
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