Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202008171
Keywords
cancer therapy; cellular signaling; inorganic nanoparticles; photothermal effect; tissue regeneration
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2019R1C1C1007384, NRF-2018M3A9E2023255, NRF-2020M2D9A3094171]
- HUST [2020kfyXJJS060]
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Inorganic nanoparticles offer advantages in the biomedical field due to their large surface area and controllable structures. They can act as therapeutic agents in targeted tissues without acute toxicity, while also regulating cellular signaling and behaviors. Challenges for developing promising inorganic NPs based therapeutic agents are discussed.
Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to their large surface area, controllable structures, diverse surface chemistry, and unique optical and physical properties. Researchers worldwide have shown that inorganic NPs and the released metal ions can act as therapeutic agents in targeted tissues or to cure various diseases without acute toxicity. In this progress report, the recent developments in inorganic NPs with different compositions directly used as therapeutics are discussed. First, the recent convergence of nanotechnology and biotechnology in biomedical applications as well as the unique functions, features, and advantages of inorganic NPs in biomedical applications are summarized. Thereafter, the biological effects of inorganic compositions in NPs which include balancing the intracellular redox environment, regulating the specific cellular signaling and cellular behaviors, and apoptosis are explained. In addition, the emerging therapeutic applications of inorganic NPs in various diseases are exemplified. Finally, the perspectives and challenges for overcoming the weaknesses of inorganic NPs as therapeutics are discussed. By carefully considering and investigating the biological effects of inorganic NPs and metal ions released from NPs, more promising inorganic NPs based therapeutic agents can be developed.
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