Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 167, Issue -, Pages 19-46Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.11.008
Keywords
Long acting injectables; Extended release; Drug delivery; PLGA microparticles; Microspheres; Implants; In situ forming implants; Drug crystals; Oil-based formulations; Drug crystal suspensions
Categories
Funding
- Next Generation Scientists Program(Novartis Pharma AG, Basel)
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Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations. (C) 2020 Elsevier B.V. All rights reserved.
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